The tropical splenomegaly syndrome

CONFERENCES AND MEETINGS Tropical Splenomegaly Syndrome

A one-day symposium was held at the Royal Postgraduate Medical School in London on 17 November. The participants comprised experts in tropical medicine, parasitology, pathology, immunology, and haematology, most of whom had had personal experience with splenomegaly in the tropics. They met to review the present state of knowledge and to define those areas where further research was likely to be...

Splenectomy for Tropical Splenomegaly

Splenectomy in tropical splenomegaly.

"Big Spleen Disease"-Hamilton et al. MEBRITCLSH 825 44%. His only treatment has been a 15-day course of primaquine followed by 100 mg. of proguanil daily. This is further evidence for a malarial cause of this syndrome and also for implicating the spleen in the plasma volume changes. The role of the spleen is also shown by a case of Felty's syndrome (Pengelly, 1966), in which a marked reduction ...

Tropical splenomegaly syndrome in a caucasian in Africa.

In recent years there has been increased interest in the tropical splenomegaly sn e and the subject has recently been reviewed (Pitney, 1968; Marsden and Hamilton, 1969; British Medical 7oural, 1969). Outside Africa pical splenomegaly syndromne has been described in the inhabitants of South Arabia (Fawdry, 1965), who anthropologically are caucasoid, in the Melanesians of New Guinea (Marsden et ...

Relapses after withdrawal of proguanil treatment in tropical splenomegaly syndrome.

After the remission of symptoms and reduction in spleen size while on proguanil therapy four patients with the tropical splenomegaly syndrome defaulted from treatment. The withdrawal of proguanil caused a recrudescence of original symptoms, splenomegaly, and a return of the initially raised serum IgM. Complete return to normal values was again effected with proguanil therapy.The role of the spl...